Insulin signaling pathways in time and space.

By Alan R. Saltiel, J. Pessin. Trends in Cell Biology, 2002

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The SLC2 family of facilitated hexose and polyol transporters (2004, background): “The ability of insulin to stimulate glucose uptake relies on a complex signalling cascade [62] that is still not understood completely.”
The exocyst complex in polarized exocytosis. (2004, positive): “It was proposed that Glut4 exocytosis takes place in the lipid raft domains of the plasma membrane in 3T3 adipocytes (Saltiel and Pessin, 2002).”
Protein tyrosine phosphatase 1B inhibitors for diabetes (2002, background): “cgi?l=3643">insulin receptor , including autophosphorylation of tyrosine (Tyr) residues in the insulin-receptor activation loop”
Inflammation, stress, and diabetes. (2005, neutral): “The stimulated insulin receptor phosphorylates itself and several substrates, including members of the insulin receptor substrate (IRS) family, thus initiating down-stream signaling events (32, 33).”