Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes.

By A. Reddy, E. Caler, N. Andrews. Cell, 2001

1,009 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/65f40067ed248e67c80324d3e4ddb042ef9c5a42

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Citations in the corpus

Defective membrane repair in dysferlin-deficient muscular dystrophy (2003, background): “Synaptotagmins are a family of proteins with a role in vesicle trafficking and fusion to the plasma membrane, and regulate important cellular events including membrane repair in certain cell type”
Understanding ultrasound induced sonoporation: definitions and underlying mechanisms. (2014, background): “Later on, research has demonstrated that influx of Ca through membrane wounds triggers exocytosis, with recruitment of intracellular vesicles such as lysosomes to the site of injury [137,138].”
The cell biology of lysosomal storage disorders (2004, neutral): “In addition, lysosomes can fuse with the plasma membrane in a Ca 2+ -regulated fashion 41–43 ,which results in the secretion of several proteins into the extracellular space,for example,cathepsin B 44 .”
Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance (2011, background): “TFEB Overexpression Induces Lysosomal Exocytosis A typical hallmark of lysosomal exocytosis is the translocation of lysosomal membrane markers to the PM (Reddy et al., 2001; Rodrı́guez et al., 1997; Yogalingam et al., 2008).”
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. (2006, neutral): “Indeed, some members of these two protein families—Syt I and Syt II (Geppert et al., 1994; Nagy et al., 2006) and otoferlin (this study)—are involved in synaptic exocytosis, whereas others—Syt VII (Chakrabarti et al., 2003; Reddy et al., 2001 ) and dysferlin (Bansal et al., 2003)—are involved in pl”
The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins (2006, background): “It has been shown that lysosomes can undergo exocytosis [46, 47 ].”
The lysosome: from waste bag to potential therapeutic target. (2013, background): “The importance of Syt VII for efficient plasma membrane repair was highlighted in experiments in which Syt VII inhibition prevented membrane resealing (Martinez et al., 2000; Reddy et al., 2001).”
Lysosomal Physiology (2015, methodology): “membrane and replace the disrupted membranes (48, 104).”
Invited Review Article: Current State of Research on Biological Effects of Terahertz Radiation (2011, background): “In addition to their waste disposal functions, lysosomes also assist in the sealing and repair of damaged plasma membranes [29] (Fig.”