Gliogenesis and glial pathology in depression.

By G. Rajkowska, J. Miguel-Hidalgo. CNS and Neurological Disorders - Drug Targets, 2007

612 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/65ef42d15c0b83afc331385592802ef938e558f0

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In Biological Psychiatry

In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, background): “…elements in these brain regions has emerged as a fundamental morphologic abnormality in major depression (Ongur et al., 1998; Hamidi et al., 2004; Rajkowska and Miguel-Hidalgo, 2007). b. Effects on Neuroendocrine Function Alteration in the function of the HPA axis is a hallmark of…”
Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders (2008, background): “, other glial cells involved in glutamate neurotransmission are also likely to be involved in glial patholog”
Neurocircuitry of Mood Disorders (2010, background): “…was abnormally reduced in the dorsal anterolateral PFC (BA 9) in MDD (Rajkowska et al, 1999), and the density of nonpyramidal neurons was decreased in the ACC and hippocampus in BD (Benes et al, 2001; Todtenkopf et al, 2005) and in the dorsal anterolateral PFC (BA9) in MDD (Rajkowska et al, 2007).”
The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission (2011, background): “For example, PFC regions of post-mortem brain samples from individuals suffering from mood disorders showed markedly reduced glial cell numbers and densit”
Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior (2012, neutral): “(Ongur et al, 1998; Hamidi et al, 2004; Rajkowska and Miguel-Hidalgo, 2007).”
Astrocytes: biology and pathology (2009, background): “Clinicopathological studies show that expression of astrocyte glutamate transporters has been found in prefrontal cortex of schizophrenic patients [137], and that the density of astrocytes is reduced in prefrontal cortex of patients with major depressive disorders [146, 189, 218].”
Towards a glutamate hypothesis of depression (2011, background): “…in a number of postmortem studies (Rajkowska, 2000; Rajkowska et al., 1999, 2001; Bowley et al., 2002; Miguel-Hidalgo et al., 2002; Webster et al., 2001; Cotter et al., 2001; Miguel-Hidalgo et al., 2000; Ongur et al., 1998; Hamidi et al., 2004) (see Rajkowska and Miguel-Hidalgo, 2007 for review).”
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression (2009, positive): “Consistent with the effect of cytokines and central inflammatory processes on glia, loss of glial elements, including oligodendrocytes and astrocytes, in multiple mood-relevant brain regions, including the subgenual prefrontal cortex and amygdala, has emerged as a fundamental morphologic abnormality”
The chemistry and biological activities of N-acetylcysteine. (2013, background): “23 neurotoxicity [237], and to inhibit NF-B-mediated LPS, IL-1, or INF--induced NO production”