Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation.

By J. Kress, A. Pohlman, M. O’Connor, J.B. Hall. New England Journal of Medicine, 2000

2,778 citations recorded by the source corpus.

Subfields: Critical Care and Intensive Care Medicine, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/659d5d36747bf4bb6c37983573ad804035c9b12a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Critical Care and Intensive Care Medicine

1. Ayumi Shintani
2. Robert S. Dittus
3. Pratik Pandharipande
4. J. Kress
5. B. Pun
6. E. W. Ely
7. Shruti B. Patel
8. Y. Skrobik

In Pulmonary and Respiratory Medicine

1. Pratik Pandharipande
2. B. Pun
3. E. W. Ely
4. J. Kress
5. Robert S. Dittus
6. Ayumi Shintani
7. B. Kavanagh

Citations in the corpus

• Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit (2013, background): “, a combination of any three of the following actions upon request: open eyes, maintain eye contact, squeeze hand, stick out tongue, and wiggle toes) (15, 16, 326).”
• Sedation and weaning from mechanical ventilation: time for ‘best practice’ to catch up with new realities? (2014, background): “The adoption by ICUs (certainly in Europe) of awake, cooperative sedation as the standard of care means that the spontaneous awakening trial [12] is now largely an anachronism, relevant only to those narrow sectors of the ICU population where deep sedation is still needed (e.”
• Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. (2008, background): “Use daily interruption or lightening of sedation to avoid constant heavy sedation and try to avoid paralytic agents, both of which can depress cough and thereby increase the risk of HAP (Level II) (120).”
• The ABCDEF Bundle in Critical Care (2017, methodology): “These data suggest that daily SAT uses less analgosedation while improving ICU outcomes.(14) There is a consistent relationship between deeper sedation and worse ICU outcomes.”
• The impact of delirium in the intensive care unit on hospital length of stay (2001, background): “In two important and recently reported clinical trials, dose reductions of narcotics and benzodiazepines have been shown to improve outcomes in the ICU for mechanically ventilated patients [44, 45] , but the effects on delirium or long-term cognitive impairment were not measured.”
• Incidence, risk factors and consequences of ICU delirium (2006, background): “Neuroleptics can be harmful [19, 20], and excess sedative use in intensive care prolongs mechanical ventilation and hospital stay [21].”
• Review: A Prospective, Randomised Study Comparing Early Percutaneous Dilational Tracheotomy to Prolonged Translaryngeal Intubation (Delayed Tracheotomy) in Critically Ill Medical Patients (2004, neutral): “Quicker extubation can also be explained by more sedation in the prolonged translaryngeal intubation group (45) and apparent less work of breathing (46) and better lung mechanics in the tracheotomized patients (47).”
• Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). (2001, neutral): “Median 51 92 (64-100) 100 (75-100) 100 (29-100) 100 (40-100)”