Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion
By Attila Becskei, Bertrand Séraphin, Luis Serrano. EMBO Journal, 2001
746 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/656870250f195a0199b557821e9ed0554e09cb62
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
- Alexander van Oudenaarden
- Arjun Raj
- James J. Collins
- Timothy C. Elston
- Thomas B. Kepler
- Ron Weiss
- Michael A. Kohanski
- J. Tyson
In Molecular Biology
- Alexander van Oudenaarden
- James J. Collins
- Arjun Raj
- Albert-László Barabási
- Boris N. Kholodenko
- J. Tyson
- Béla Novák
- Zoltn Oltvai
Citations in the corpus
- Bistability, epigenetics, and bet-hedging in bacteria. (2008, background): “coli and Saccharomyces cerevisiae, autostimulatory regulation systems can function as memory devices in microorganisms (13, 36).”
- The second wave of synthetic biology: from modules to systems (2009, background): “The role of feedback in attenuating noise is complex and depends on both input level and feedback strengt”
- Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades (2004, background): “Under proper condition, bistability can arise from substrate inhibition or product activation in metabolic pathways (Sel’kov, 1975) or from a double-negative feedback or positive feedback in artificial genetic circuits in Escherichia coli and Saccharomyces cerevisiae (Gardner et al., 2000; Becskei e”
- Robustness of Cellular Functions (2004, neutral): “feedback (Gardner et al., 2000; Becskei et al., 2001). topologies, that is, the (static or dynamic) pattern of”
- Bistability in bacteria (2006, background): “The first involves a positive transcriptional autoregulatory loop together with cooperativity in promoter activation (Becskei et al., 2001).”
- Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations. (2001, background): “This type of regulation is thought to play a role in the developmental decision pathway of bacteriophage (Ptashne, 1992) and has been used to construct a synthetic eukaryotic gene switch in Saccharomyces cerevisiae (Becskei et al., 2001).”