ICE1: a regulator of cold-induced transcriptome and freezing tolerance in Arabidopsis.

By Viswanathan Chinnusamy, Masaru Ohta, S. Kanrar, Byeong-ha Lee, Xuhui Hong, Manu Agarwal, Jian‐Kang Zhu. Genes & Development, 2003

1,626 citations recorded by the source corpus.

Cold temperatures trigger the expression of the CBF family of transcription factors, which in turn activate many downstream genes that confer chilling and freezing tolerance to plants. We report here the identification of ICE1 (inducer of CBF expression 1), an upstream transcription factor that regulates the transcription of CBF genes in the cold. An Arabidopsis ice1 mutant was isolated in a screen for mutations that impair cold-induced transcription of a CBF3 promoter-luciferase reporter gene. The ice1 mutation blocks the expression of CBF3 and decreases the expression of many genes downstream of CBFs, which leads to a significant reduction in plant chilling and freezing tolerance. ICE1 encodes a MYC-like bHLH transcriptional activator. ICE1 binds specifically to the MYC recognition sequences in the CBF3 promoter. ICE1 is expressed constitutively, and its overexpression in wild-type plants enhances the expression of the CBF regulon in the cold and improves freezing tolerance of the transgenic plants.

Subfields: Plant Science

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Citations in the corpus

UvA-DARE ( Digital Academic Repository ) Rapid phosphatidic acid accumulation in response to low temperature stress in Arabidopsis is generated through diacylglycerol kinase (2017, background): “In Arabidopsis, several COR mutants have been identified, including ice1, snow1, fry1, hos1, and los1 [(Ishitani et al., 1998; Xiong et al., 2001; Guo et al., 2002; Chinnusamy et al., 2003) mutation has been demonstrated to negatively affect cold-induced gene transcription by interfering with the fu”
Gene regulation during cold acclimation in plants (2006, background): “CBF2 expression levels may be regulated by CBF3, because impaired CBF3 expression in the ice1 mutant is accompanied by enhanced expression of CBF2 (Chinnusamy et al. 2003 ).”
The Arabidopsis Basic/Helix-Loop-Helix Transcription Factor Family Online version contains Web-only data. Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.013839. (2003, background): “…ATR2 is involved in tryptophan biosynthesis (Smolen et al., 2002), BEE1, BEE2, and BEE3 are involved in brassinosteroid signaling (Friedrichsen et al., 2002), and ICE1 is involved in chilling and freezing tolerance responses (Chinnusamy et al., 2003) (summarized in supplemental Table 4 online).”
Cold stress regulation of gene expression in plants. (2007, background): “Thus, MYB15 is an upstream transcription factor that negatively regulates the expression of CBFs [32] (Figure 1). Interestingly, ICE1 can negatively regulate MYB15 as indicated from the increased MYB15 transcript level in ice1 mutant compared with wild-type plants under cold stress [ 29 ,32].”
Cold stress tolerance mechanisms in plants. A review (2010, background): “Genetic analysis of mutants led to the iden-tiﬁcation of an inducer of dehydration-responsive elements or C-repeat binding factor expression-1 as an activator of dehydration-responsive elements or C-repeat binding factor-3 (Chinnusamy et al., 2003).”
Cold Acclimation Threshold Induction Temperatures in Cereals (2008, background): “The ICE1 genes ( Chinnusamy et al., 2003 ), which are constitutively expressed in Arabidopsis, and cold shock proteins (Nakaminami et al., 2006) have been implicated in the regulation of cold response transcriptional activators.”
Regulation of water, salinity, and cold stress responses by salicylic acid (2014, background): “The ice1 mutant, which was originally isolated as a cold-sensitive mutant (Chinnusamy et al., 2003), exhibited an up-regulation of SA-inducible genes (Miura and Ohta, 2010) and enhanced resistance to bacterial pathogens (Zhu et al., 2011).”
Lipids in Plant and Algae Development (2016, background): “Chem Nat Compd 38:223–229 Khozin I, Adlerstein D, Bigongo C, Heimer YM, Cohen Z (1997) Elucidation of the biosynthesis of eicosapentaenoic acid in the microalga Porphyridium cruentum (II. Studies with radiolabeled precursors). Plant Physiol 114:223–230 Khozin-Goldberg I, Cohen Z (2006) The effect of”
Abiotic stress response in plants : when post-transcriptional and post-translational regulations control transcription (2008, background): “ICE1 is constitutively expressed, nevertheless it activates the expression of CBF genes only upon cold treatment [121].”
Jasmonate Regulates the INDUCER OF CBF EXPRESSION–C-REPEAT BINDING FACTOR/DRE BINDING FACTOR1 Cascade and Freezing Tolerance in Arabidopsis[W] (2013, methodology): “Expression of CBF3/DREB1a and its downstream target genes is downregulated in ice1 mutants; ice1 plants consequently display significantly reduced cold acclimation-induced freezing tolerance (Chinnusamy et al., 2003).”
What happens in plant molecular responses to cold stress? (2010, background): “…which binds to CBF/DREB1 promoter regions to repress its expression and negatively regulate FT. Interestingly, ICE1 can negatively regulate MYB15 as indicated from the increased MYB15 transcript level in ice1 mutant compared with wild-type plants under cold stress (Chinnusamy et al. 2003).”
Transcription factors in plants and ABA dependent and independent abiotic stress signalling (2010, background): “The DREB1/CBF genes were also regulated by bHLH-type of transcription factor, ICE1 (Chinnusamy et al. 2003), and by Ca related processes, because mutations in CAX1 (encoding a Ca/H transporter) and CBL1 (Ca-sensor protein) affected expression pattern of DREB1/CBF genes (Albrecht et al.”
Advances in physiological and molecular aspects of plant cold tolerance (2017, positive): “Chinnusamy et al. (2003) reported that ICE1, which is a nuclear gene encoding a MYC-like bHLH protein, has a crucial role in regulating some CBF genes.”