The Hox genes and their roles in oncogenesis

By Nilay Shah, S. Sukumar. Nature Reviews. Cancer, 2010

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The JmjC domain‐containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene (2012, background): “Hox genes are a highly conserved subgroup of the homeobox superfamily which have crucial roles in development, regulating numerous processes, including apoptosis, receptor signaling, differentiation, motility and angiogenesis.(39) The majority of examples of aberrant Hox gene expression have been fo”
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia (2011, background): “Notably, we found that several HOX family genes and the IDH1 (isocitrate dehydrogenase 1), which are associated with acute myeloid leukemia pathogenesi”
GENeration (2015, neutral): “Once the "front-end" concept was working, the remaining conversion effort, to get all of NASTRAN on a "4G" computer, while involving significant volumes of code, would not require the further system type extensions.”