Histological Typing of Endocrine Tumours

By E. Solcia, G. Klöppel, Leslie Sobin. International Histological Classification of Tumours, 2000

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Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): the NORDIC NEC study. (2013, background): “These tumors were previously defined as poorly differentiated endocrine carcinoma [4].”
TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system (2007, background): “G3 indicates a poorly differentiated neuroendocrine carcinoma with high mitotic counts/Ki-67 index, fields of necrosis, significantly reduced chromogranin A expression and intense staining for synaptophysin, meeting the current WHO histological criteria [5, 8, 34].”
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids. (2015, background): “Liver metastases derive the majority of their blood supply from the hepatic arteries; therefore, selective embolization with either bland particles (transarterial embolization, TAE) or cytotoxics such as doxorubicin (TACE) are found to be effective in improving symptoms and radiological response, pa”
Epigenetics: The Science of Change (2006, methodology): “The size limits indicated for T1 are those defined by the WHO for tumors with “benign behavior” according to site-specific clinicopathological correlations [5, 7, 31].”