TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system
By G. Rindi, G. Klöppel, A. Couvelard, P. Komminoth, M. Körner, J. Lopes, A. McNicol, O. Nilsson, A. Perren, A. Scarpa and 2 more. Virchows Archiv, 2007
974 citations recorded by the source corpus.
Criteria for the staging and grading of neuroendocrine tumors (NETs) of midgut and hindgut origin were established at the second Consensus Conference in Frascati (Rome) organized by the European Neuroendocrine Tumor Society (ENETS). The proposed tumor–node–metastasis (TNM) classifications are based on the recently published ENETS Guidelines for the Diagnosis and Treatment of gastroenteropancreatic NETs and follow our previous proposal for foregut tumors. The new TNM classifications for NETs of the ileum, appendix, colon, and rectum, and the grading system were designed, discussed, and consensually approved by all conference participants. These proposals need to be validated and are meant to help clinicians in the stratification, treatment and follow-up of patients.
Subfields: Epidemiology, Neurology, Oncology
View Paper: https://www.semanticscholar.org/paper/476d4ee0828ee83fccc86dba394bb149e5e4da3e
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Oncology
Citations in the corpus
- Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low- to intermediate-grade neuroendocrine tumors: results of a phase II study. (2008, result): “Ki-67 staining is an immunohistochemical marker of proliferation that is prognostic of outcome and has been proposed as a grading criteria for neuroendocrine tumors.(28) Consistent with our finding of disease stabilization and minor responses in a majority of patients with RAD001, we also observed d”
- The Pathologic Classification of Neuroendocrine Tumors: A Review of Nomenclature, Grading, and Staging Systems (2010, methodology): “The concept that some well-differentiated tumors could nonetheless be biologically high grade has been proposed but is controversial.33 The systems of nomenclature reflect differentiation and grading features of NETs.”