Cohesin mediates transcriptional insulation by CCCTC-binding factor

By K. Wendt, Keisuke Yoshida, T. Itoh, M. Bando, Birgit Koch, Erika Schirghuber, S. Tsutsumi, G. Nagae, Ko Ishihara, Tsuyoshi Mishiro and 8 more. Nature, 2008

1,252 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/64627e9d84e68fb4d8725366e0e8d9d6be3ad142

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In Molecular Biology

1. Richard A. Young
2. V. Corces
3. Tong Ihn Lee
4. Denes Hnisz
5. Bing Ren
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Citations in the corpus

• Transcriptional Regulation and its Misregulation in Disease (2013, neutral): “Thus, cohesin is thought to have roles in transcription activation at some genes and in silencing at others (Dorsett, 2011; Hadjur et al., 2009; Parelho et al. 2008; Phillips and Corces, 2009; Schmidt et al., 2010; Seitan and Merkenschlager, 2012; Wendt et al. 2008).”
• Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells (2013, background): “Finally, cohesin was shown to be important for CTCF’s chromatin insulation function (3–5), whereas CTCF is necessary to recruit cohesin to the shared binding sites but not to chromatin (3).”
• The long-range interaction landscape of gene promoters (2012, background): “It has been reported that CTCF acts in conjunction with the cohesin complex to block promoter–enhancer interactions 27 .”
• Architectural protein subclasses shape 3D organization of genomes during lineage commitment. (2013, positive): “In the case of cohesin, a protein with a well-known architectural function during mitosis, recent reports have suggested a critical mechanistic role in insulation based on the finding that CTCF and cohesin colocalize across the genome at thousands of loci (Parelho et al., 2008; Wendt et al., 2008).”
• Cohesin loss eliminates all loop domains (2017, background): “INTRODUCTION Many studies have shown that the insulator protein CTCF and the ring-shaped cohesin complex colocalize on chromatin (Wendt et al., 2008) and lie at the anchors of loops (Rao et al., 2014; Splinter et al., 2006) and the boundaries of contact domains (also called “topologically…”
• Functional and mechanistic diversity of distal transcription enhancers (2011, neutral): “Interestingly, CTCF associates with cohesins, protein complexes that physically connect sister chromatids during mitosis and meiosis, and this association appears to be necessary for enhancer-blocking activity (Rubio et al., 2008; Wendt et al., 2008).”
• Distinct Epigenomic Landscapes of Pluripotent and Lineage-committed Human Cells (2010, background): “Early evidence supports this hypothesis (Shi et al., 2008a, 2008b; Wendt et al., 2008).”
• Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes (2014, neutral): “Cohesin also becomes associated with CTCFbound regions of the genome and some of these cohesin-associated CTCF sites facilitate gene activation while others may function as insulators (Dixon et al., 2012; Parelho et al., 2008; Phillips-Cremins and Corces, 2013; Seitan et al., 2013; Wendt et al., 200”
• CTCF Binding Polarity Determines Chromatin Looping. (2015, background): “Cohesin also actively contributes to loop formation, possibly through its capacity to embrace and hold together two DNAmolecules (Hadjur et al., 2009; Kagey et al., 2010; Parelho et al., 2008; Wendt et al., 2008).”