Programmable cells: interfacing natural and engineered gene networks.

By Hideki Kobayashi, M. Kaern, M. Araki, Kristy Chung, T. Gardner, C. Cantor, James J. Collins. Proceedings of the National Academy of Sciences of the United States of America, 2004

625 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6432248a070b54c9c6c4c275e9d219908ce100cc

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Citations in the corpus

Current approaches to gene regulatory network modelling (2007, methodology): “Predictions of small models have been successfully tested experimentally using specifically engineered control circuits, such as feed forward loops [98] and feedback loops [99-103].”
A Synthetic Genetic Edge Detection Program (2009, background): “These include a genetically-encoded turbidostat (You et al., 2004), one (Kobaya- shi et al., 2004) and two (Brenner et al., 2007) cell density-depen- dent transcription regulators, a transcriptional pulse generator (Basu et al., 2004), synthetic ecosystems (Balagadde et al., 2008; Weber et al.,…”
Paper-based Synthetic Gene Networks (2014, positive): “In doing so, synthetic biologists have created whole-cell biosensors (Kobayashi et al., 2004; Kotula et al., 2014), synthetic probiotics, new sources of drugs (Fossati et al., 2014), green energy, (Torella et al., 2013) and chemistry (Zhang et al., 2012; Martin et al., 2003).”
Validation of qualitative models of genetic regulatory networks by model checking: analysis of the nutritional stress response in Escherichia coli (2005, neutral): “In a different context, Kuepfer et al. (2007) have recently developed an approach based on semidefinite programming for partitioning the parameter space of polynomial differential equation models into so-called feasible and infeasible regions.”
Diversity in times of adversity: probabilistic strategies in microbial survival games. (2005, positive): “mics, cellular engineering (Kobayashi et al., 2004), and evolutionary game theory, an important addition to the Systems Biology toolbox (Kitano, 2002; Levchenko, 2003; Sauro et al.”
A synchronized quorum of genetic clocks (2010, neutral): “…23 have inspired the design and construction of circuits capable of controlling cellular population growth 24 , generating specific patterns 25 , triggering biofilm development 26 , shaping intracellular noise 27 , detecting edges in an image 28 , and counting discrete cellular events 29 .”