Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host
By Bin-Hye Choi, M. Choudhary, J. Regan, J. Sparks, R. Padera, X. Qiu, I. Solomon, H. Kuo, J. Boucau, K. Bowman and 22 more. New England Journal of Medicine, 2020
1,092 citations recorded by the source corpus.
SARS-CoV-2 in an Immunocompromised Host This letter describes an immunocompromised patient who had persistent infection with SARS-CoV-2 over a period of months, despite several courses of remdesivi...
Subfields: Infectious Diseases, Obstetrics and Gynecology
View Paper: https://www.semanticscholar.org/paper/64294631ac99891d6cf0eb35a95701a51ac1071b
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Infectious Diseases
Citations in the corpus
- Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil (2021, background): “7 lineage exhibits similar evolutionary characteristics (13), which was hypothesised to have occurred in a chronically infected or immunocompromised patient (33, 34).”
- Adaptive immunity to SARS-CoV-2 and COVID-19 (2021, neutral): “Viral replication in immunocompromised patients can last 100 days or more (Avanzato et al., 2020; Choi et al., 2020), not unlike what is observed for poliovirus, which can replicate in the gut of immunocompromised individuals for months in the absence of any reported clinical symptoms (Burns et al.”
- Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape (2021, background): “We and others have reported the acquisition of deletions in the amino 46 (N)-terminal domain (NTD) of the S glycoprotein during long-term infections of often-immunocompromised 47 patients (12-15).”
- Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein (2021, neutral): “Since the start of the outbreak, circulating SARS-CoV-2 field strains have acquired genetic changes that facilitate transmission (Avanzato et al., 2020; Choi et al., 2020; Hou et al., 2020; Kemp et al., 2020; McCarthy et al., 2020; Plante et al., 2020; Rambaut et al., 2020; Tegally et al., 2020).”