Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells
By J. Nougayrède, Stefan Homburg, F. Taieb, M. Boury, E. Brzuszkiewicz, G. Gottschalk, C. Buchrieser, J. Hacker, U. Dobrindt, É. Oswald. Science, 2006
1,085 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology, Molecular Medicine
View Paper: https://www.semanticscholar.org/paper/63f51a0e96b08b209560ac7abb474e4cb52f8488
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In Genetics
In Molecular Biology
- Michael A. Fischbach
- Mohamed S. Donia
- B. Goodman
- Peter Cimermancic
- Jon Clardy
- H. Gardner
- Sivaraman Balakrishnan
- David S. Eisenberg
In Molecular Medicine
Citations in the corpus
- American Gut: an Open Platform for Citizen Science Microbiome Research (2018, neutral): “Colibactin triggers DNA double-strand breaks in eukaryotic cells (96, 97) and induces cellular senescence and metabolic reprogramming in affected mammalian cells (98).”
- Prostate cancer and inflammation: the evidence (2012, background): “coli which harbour a ‘pks’ genomic island responsible for synthesis of a peptide–polyketide hybrid cytotoxin (termed colibactin) have been shown to induce DNA double-strand breaks (DSBs) in human cells.(31) Strains of E.”
- A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics (2014, background): “, 2010), the Escherichia coli metabolite colibactin was found to contribute to colon cancer (Nougayrède et al., 2006), and polysaccharide A from Bacteroides fragilis has been shown to suppress the gut mucosal immune response (Mazmanian et al.”
- Intestinal inflammation targets cancer-inducing activity of the microbiota (2012, methodology): “The genotoxic effect of pks requires bacteria-host cell contact (15, 16), thus an environment in which bacteria can more readily access the epithelium could result in increased delivery of the pks product Colibactin to epithelial host cells.”
- Small Molecules from the Human Microbiota (2015, neutral): “coli B2, Enterobacter aerogenes, Klebsiella pneumoniae, and Citrobacter koseri (113, 114).”
- Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells (2010, methodology): “The clbA gene is localized on the pks island and encodes a phosphopantetheinyl transferase required for Colibactin biosynthesis by theNRPS and PKS enzymes (4).”
- The microbiome and cancer (2018, background): “Over time, DNA damage results in increased mutational loads.”