Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

By Gabriel Cuevas-Ramos, C. Petit, I. Marcq, M. Boury, É. Oswald, J. Nougayrède. Proceedings of the National Academy of Sciences of the United States of America, 2010

804 citations recorded by the source corpus.

Subfields: Endocrinology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7070ec79469e420876bdd29336fd5475d752f59e

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In Molecular Biology

1. G. A. Weiss
2. T. Hennet
3. Sivaraman Balakrishnan
4. David S. Eisenberg
5. ChristopherA. Miller

Citations in the corpus

• Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin (2013, background): “Previous studies have provided mechanistic insights into the microbial involvement in the development of CRC (Arthur et al., 2012; Cuevas-Ramos et al., 2010; Lee et al., 2010; Wu et al., 2009).”
• Intestinal inflammation targets cancer-inducing activity of the microbiota (2012, methodology): “The genotoxic effect of pks requires bacteria-host cell contact (15, 16), thus an environment in which bacteria can more readily access the epithelium could result in increased delivery of the pks product Colibactin to epithelial host cells.”
• Mechanisms and consequences of intestinal dysbiosis (2017, background): “Colibactin causes DNA double-strand breaks and incomplete DNA repair resulting in genomic instability [229].”