TGF-β signaling in cancer – a double-edged sword

667 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. (2008, background): “Mutations of the genes encoding TbRI and TbRII (TGFBR1 and TGFBR2, respectively ) have been reported in a number of human cancers (Akhurst and Derynck, 2001).”
Tumour microenvironment: TGFβ: the molecular Jekyll and Hyde of cancer (2006, neutral): “In addition to the well-characterized interactions that are known to regulate Smad activity, which are detailed in several review article”
Signaling mechanisms of the epithelial-mesenchymal transition (2014, background): “Most systems in which EMT is observed, including cancer and fibrosis, are regulated by TGF-β1 (69), whereas TGF-β2 primarily controls EndMT in heart development (70), and TGF-β3 mediates EMT in the developing palate (28).”
Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “Therefore, in some carcinomas, TGF- signaling can have biphasic effects, inhibiting tumor initiation yet promoting the high-grade advancement of established tumors (Akhurst and Derynck 2001).”