Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers.

By R. Hong, Gang Han, Joseph M. Fernandez, Byoung-jin Kim, Neil S. Forbes, Vincent Rotello. Journal of the American Chemical Society, 2006

760 citations recorded by the source corpus.

We demonstrate here the effective delivery of a dye payload into cells using 2-nm core gold nanoparticles, with release occurring via place exchange of glutathione onto the particle surface. In vitro experiments demonstrate effective release of drug analogues upon addition of glutathione. Cell culture experiments show rapid uptake of nanoparticle and effective release of payload. The role of glutathione in the release process was demonstrated through improved payload release upon transient increase in glutathione levels achieved via introduction of glutathione ethyl ester into the cell.

Subfields: Electronic, Optical and Magnetic Materials, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/63d223325fcc832d5843f13a1f511858c04cf370

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Electronic, Optical and Magnetic Materials

1. A. Chaudhari
2. Chaekyu Kim
3. Vincent Rotello
4. Arun G. Ingale
5. F. Stellacci
6. I. Lo
7. S. Tang

In Materials Chemistry

1. A. Chaudhari
2. Gang Han
3. Vincent Rotello
4. Arun G. Ingale
5. J. Patra
6. Kwang-Hyun Baek

In Molecular Biology

1. A. Chaudhari
2. Mrinmoy De
3. D. Irvine
4. Vincent Rotello
5. Arun G. Ingale
6. P. Ghosh
7. S. Tang
8. I. Lo

Citations in the corpus

• Biogenic Synthesis of Nanoparticles and Potential Applications: An Eco- Friendly Approach (2013, background): “Volume 4 • Issue 2 • 1000165 J Nanomed Nanotechol ISSN:2157-7439 JNMNT, an open access journal fluorophore [88].”
• Gold nanoparticles in delivery applications. (2008, background): “This methodology relies on the dramatic differential in intracellular GSH concentration (1–10 mM) [33,34] versus extracellular thiol levels [35], where the predominant thiols in blood plasma are glutathione (2 μM) and cysteine (8 μM) [36].”
• Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles. (2008, background): “This effect seems unlikely given that glutathione-mediated displacement has been shown to require timescales of the order of day”