Flavonoids in Cancer and Apoptosis
By Mariam Abotaleb, S. Samuel, E. Varghese, Sharon Varghese, P. Kubatka, A. Líšková, Dietrich Büsselberg. Cancers, 2018
656 citations recorded by the source corpus.
Cancer is the second leading cause of death globally. Although, there are many different approaches to cancer treatment, they are often painful due to adverse side effects and are sometimes ineffective due to increasing resistance to classical anti-cancer drugs or radiation therapy. Targeting delayed/inhibited apoptosis is a major approach in cancer treatment and a highly active area of research. Plant derived natural compounds are of major interest due to their high bioavailability, safety, minimal side effects and, most importantly, cost effectiveness. Flavonoids have gained importance as anti-cancer agents and have shown great potential as cytotoxic anti-cancer agents promoting apoptosis in cancer cells. In this review, a summary of flavonoids and their effectiveness in cancer treatment targeting apoptosis has been discussed.
Subfields: Biochemistry, Endocrinology, Diabetes and Metabolism, Pharmacology
View Paper: https://www.semanticscholar.org/paper/2338f2a97960a1540977d2c6478a474ac4a90d57
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- D. Kopustinskiene
- R. Al-Ishaq
- V. Jakštas
- A. Savickas
- P. Kubatka
- J. Bernatonienė
- K. Kajo
- Dietrich Büsselberg
Citations in the corpus
- Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels (2019, background): “Flavonoids are considered as a class of biologically active secondary metabolites of plants known as pigment producers accountable for the odor and color of the flowers, where they serve antiviral, anti-allergic, antibacterial and anti-inflammatory functions [50].”
- Flavonoids as Anticancer Agents (2020, background): “could be further classified into 6 major groups: isoflavonoids, flavanones, flavanols, flavonols, flavones and anthocyanidins [20,22,23].”