Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition

By F. Wendling, F. Bartolomei, J. Bellanger, P. Chauvel. European Journal of Neuroscience, 2002

633 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6332d83b06391a5f44ddc7e5d8c9beef6695982a

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Citations in the corpus

On the nature of seizure dynamics. (2014, background): “Many of these models find applications in epilepsy (Wendling et al., 2002; Breakspear et al., 2006; Kramer et al., 2012; Wang et al., 2012).”
Criticality in the brain: A synthesis of neurobiology, models and cognition. (2017, background): “interactions between excitatory and inhibitory cortical neurons due to GABA-ergic dysfunction (Wendling et al., 2002).”
Synchronization and desynchronization in epilepsy: controversies and hypotheses (2012, background): “…suppressed action potential firing at seizure initiation, while local (mainly somatic-projecting) interneurons demonstrate sustained and intensive discharges resulting in prominent and fast inhibitory postsynaptic potentials in principal cells (Wendling et al. 2002; de Curtis & Gnatkovsky 2009).”
Seizure prediction: the long and winding road. (2007, background): “A further promising approach is to model EEG signals to gain insight into the dynamical processes involved in seizure generation (Wendling et al., 2002, 2003; Suffczynski et al., 2005, 2006).”
Modelling event-related responses in the brain (2005, background): “This means, in principle, generative models of the sort employed above could be used to characterise the pathophysiological mechanisms underlying seizure activity (Robinson et al., 2002;Wendling et al., 2002).”
The Dynamic Brain: From Spiking Neurons to Neural Masses and Cortical Fields (2008, background): “Experimental and theoretical arguments propose that the onset of a seizure reflects a bifurcation in cortical activity from damped stochastic activity—where peaks in the power spectrum reflect damped linear resonances—to high amplitude nonlinear oscillations arising from activity on a limit cycle or”
A neural mass model for MEG/EEG: : coupling and neuronal dynamics (2003, methodology): “They can also be used to reconstruct a posteriori the scenario of inhibition/ excitation balance during epileptic seizures (Wendling et al., 2002).”