Collective cell guidance by cooperative intercellular forces
By D. Tambe, C. Hardin, T. Angelini, K. Rajendran, C. Park, Xavier Serra-Picamal, E. Zhou, M. Zaman, J. Butler, David A. Weitz and 2 more. Nature Materials, 2010
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Cells comprising a tissue migrate as part of a collective. How collective processes are coordinated over large multi-cellular assemblies has remained unclear, however, because mechanical stresses exerted at cell-cell junctions have not been accessible experimentally. We report here maps of these stresses within and between cells comprising a monolayer. Within the cell sheet there arise unanticipated fluctuations of mechanical stress that are severe, emerge spontaneously, and ripple across the monolayer. This stress landscape becomes increasingly rugged, sluggish, and cooperative with increasing system density. Within that landscape, local cellular migrations follow local orientations of maximal principal stress. Migrations of both endothelial and epithelial monolayers conform to this behavior, as do breast cancer cell lines before but not after the epithelial-mesenchymal transition. Collective migration in these diverse systems is seen to be governed by a simple but unifying physiological principle: neighboring cells join forces to transmit appreciable normal stress across the cell-cell junction, but migrate along orientations of minimal intercellular shear stress.
Subfields: Biomedical Engineering, Cell Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/630dee90c72e2e27fb46d8cdfa89a0d5352d4fc0
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Citations in the corpus
- Unjamming and cell shape in the asthmatic airway epithelium (2015, methodology): “2a–c,g and Supplementary Movie 2), whereas cells from a representative asthmatic donor became jammed only by day 14 (Fig.”
- Cancer invasion and the microenvironment: plasticity and reciprocity. (2011, positive): “In collective migration, protrusion and retraction are coordinated in a ‘‘supracellular manner,’’ in which cytoskeletal protrusion and contractility are mechanically mediated through cell-cell junctions (Hidalgo-Carcedo et al., 2011; Tambe et al., 2011), allowing the cell group to behave as ‘‘mega-c”