Predicting the impact of physiological and biochemical processes on oral drug bioavailability.

By B. Agoram, W. Woltosz, M. Bolger. Advanced Drug Delivery Reviews, 2001

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PBPK models for the prediction of in vivo performance of oral dosage forms. (2014, background): “For all the drugs investigated, absorption was considered to occur from the small intestinal compartments, with the exception of saquinavir, where colonic absorption was also incorporated, in agreement with previous reports (Agoram et al., 2001).”
A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recognition of covariates. (2009, background): “133) This model puts more emphasis on formulation and drug related processes than CAT including release, dissolution, precipitation and degradation.”