Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity.

By O. Nakano, M. Sato, Yoshitaka Naito, Kensho Suzuki, S. Orikasa, M. Aizawa, Yasuyoshi Suzuki, I. Shintaku, H. Nagura, H. Ohtani. Cancer Research, 2001

673 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/62da62c04af50c3741be99f647361d49123bf1f9

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Citations in the corpus

Inflammation, a Key Event in Cancer Development (2006, background): “The infiltration of immune cells to tumors may repress tumor growth (49-57).”
The tumor microenvironment and its role in promoting tumor growth (2008, background): “At the same time, equally numerous reports have indicated a lack of significant correlations between lymphocytic infiltrate intensity and improved prognosis or have linked immune cell infiltration to a poor prognosis (Stewart and Tsai, 1993; Sheu et al., 1999; Nakano et al., 2001).”
Integrative Clinical Genomics of Metastatic Cancer (2017, unknown): “9b), including kidney cancer 31,32 , lung cancer 33 , and melanoma 34 , remained infiltrated at metastatic sites.”
Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. (2007, methodology): “Granzyme B–positive cells with a sparsely granulated pattern were evaluated as activated CTLs, and densely positive natural-killer cells were excluded.(23,24) The evaluation of TILs was performed without knowledge of the clinicopathologic data by two independent investigators.”
Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. (2006, background): “High levels of infiltrating T cells within RCC tumors are frequently observed but paradoxically associated with diminished cancer-specific patient survival (18).”
PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer. (2013, result): “It should also be mentioned that in contrast to many tumors, CD8T cells are associated with bad prognosis in renal cell carcinoma and hodgkin lymphoma supporting the fact that the clinical significance of molecules expressed by these cells could also vary depending on the tumor histology (35, 36).”