The structure of the nervous system of the nematode Caenorhabditis elegans.

By J. White, Erica L. Southgate, J. Thomson, S. Brenner. 1986

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In Neuroscience

Citations in the corpus

Weight Agnostic Neural Networks (2019, background): “While it is a challenge to map out the human connectome [102], with our 90 billion neurons and 150 trillion synapses, the connectome of simple organisms such as roundworms [112, 114] has been constructed, and recent works [20, 105] mapped out the entire brain of a small fruit ﬂy.”
Small-World Brain Networks Revisited (2016, unknown): “Using data on the synaptic and gap junction connectivity between all N = 302 neurons in the nervous system of Caenorhabditis elegans [9], a binary undirected graph was constructed representing each neuron as an identical node and each synapse ( ∼ 5000) or gap junction ( ∼ 600) as an identical,…”
Crowdsourcing the creation of image segmentation algorithms for connectomics (2015, methodology): “Serial EM has been most famously used to reconstruct the connectivity of the Caenorhabditis elegans nervous system (White et al., 1986; Jarrell et al., 2012).”
Comprehensive Maps of Drosophila Higher Olfactory Centers: Spatially Segregated Fruit and Pheromone Representation (2007, unknown): “While new EM technologies are under development (Denk and Horstmann, 2004), traditional serial section transmission EM approaches are so labor intensive that this has only been achieved once—the reconstruction of the nervous system of C. elegans hermaphrodites (White et al., 1986).”
Structural Properties of the Caenorhabditis elegans Neuronal Network (2009, background): “The new version of the wiring diagram incorporates originald ta from Whiteet al. [7], Hall and Russell [10], updates based upon later work [8], [28], as well as new reconstructions.”
Convolutional Networks Can Learn to Generate Affinity Graphs for Image Segmentation (2010, background): “White et al. (1986) took over 10 years to complete the manual reconstruction of the entire nervous system of a nematode worm C. elegans, which contains only 302 neurons, underscoring the need for significant automation.”
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. (2001, background): “…receptor gene encodes a close relative of the insulin receptor that is not activated by any of the known human insulin-like ligands (Zhang and Roth 1992; Watt et al. 1993), and there are other suggestions that additional insulin-like genes exist in humans (Villa-Komaroff et al. 1984; Rotwein…”
The human connectome: Origins and challenges (2013, background): “Nevertheless, the notion that circuit anatomy is critical for explaining function resurfaced numerous times over the past century, most notably with the compilation of the nearly complete cellular connection map of the nematode Caenorhabditis elegans by Sydney Brenner and colleagues (White et al., 1”