Ran Induces Spindle Assembly by Reversing the Inhibitory Effect of Importin α on TPX2 Activity

By O. Gruss, Rafael Edgardo Carazo-Salas, C. Schatz, G. Guarguaglini, J. Kast, M. Wilm, N. Bot, I. Vernos, E. Karsenti, I. Mattaj. 2001

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Human TPX2 is required for targeting Aurora-A kinase to the spindle (2002, methodology): “Most recently, TPX2 was also identified as a critical component involved in promoting the RanGTP-regulated nucleation of MTs in the vicinity of chromosomes (Gruss et al., 2001).”
Importin α mRNAs have distinct expression profiles during spermatogenesis (2006, background): “…been shown that importin 2, in addition to its role in nuclear import, can inhibit mitotic spindle formation by binding to TPX2, an assembly factor (Gruss et al., 2001; Schatz et al., 2003), and the C. elegans germ-line-specific importin , IMA-2, has been shown to participate in nuclear envelope…”
Microtubule nucleation: γ-tubulin and beyond (2006, background): “Although it is not required for MT nucleation by the centrosome, TPX2 was found to be essential for mitotic spindle assembly, functioning as a crucial regulator of MT assembly in the vicinity of mitotic chromosomes (Gruss et al., 2001; Gruss et al., 2002; Schatz et al., 2003).”