Ageing, neurodegeneration and brain rejuvenation

By T. Wyss‐Coray. Nature, 2016

983 citations recorded by the source corpus.

Although systemic diseases take the biggest toll on human health and well-being, increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the essence of being. Ageing, which is fundamental to neurodegeneration and dementia, affects every organ in the body and seems to be encoded partly in a blood-based signature. Indeed, factors in the circulation have been shown to modulate ageing and to rejuvenate numerous organs, including the brain. The discovery of such factors, the identification of their origins and a deeper understanding of their functions is ushering in a new era in ageing and dementia research.

Subfields: Biological Psychiatry, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/623cc8a8e9a26111ae35c8d27942c232394fd44d

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Citations in the corpus

A Deep Learning Approach for Automated Diagnosis and Multi-Class Classification of Alzheimer’s Disease Stages Using Resting-State fMRI and Residual Neural Networks (2019, background): “…years, the growth of neurodegenerative disorders such as AD has gained much interest from researchers worldwide to develop high performing methods for diagnosis, treatment, preventive therapies, and target drug discovery by studying the pathological processes associated with each stage of AD [11].”
High‐Dimensional Single‐Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease (2018, neutral): “, 2016), protein accumulation (David, 2012), neurodegeneration (Krasemann et al., 2017; Wyss-Coray, 2016), and/ or increased inflammatory mediators (Deleidi et al.”