Toxicity assessments of multisized gold and silver nanoparticles in zebrafish embryos.

By Ofek Bar-Ilan, R. Albrecht, Valerie Fako, D. Furgeson. Small, 2009

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Potential of plant as a biological factory to synthesize gold and silver nanoparticles and their applications (2012, background): “In general, factors determining the degree of toxicity include the chemistry of nanoparticles (Bar-Ilan et al. 2009), particle size (Semmler-Behnke et al. 2008), and specificity to cell types (Soto et al. 2007).”
Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? (2010, positive): “While most of the in vivo studies have been performed using land animal models (mice, rats, and pigs), Bar-Ilan et al. (2009) used zebrafish embryo screening methods to assess the toxicity of both gold and silver nanoparticles of different sizes (3, 10, 50, and 100 nm).”
A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity (2010, background): “The authors reported no significant effect on mitochondrial function or GSH content at any of the concentrations investigated (up to 2.4 μg/ml), when exposed for 72 hours. These concentrations are relatively low for those used in most in vitro studies. Given the propensity for particles to accumulat”