Local Delivery of Marrow-Derived Stromal Cells Augments Collateral Perfusion Through Paracrine Mechanisms

By T. Kinnaird, E. Stabile, M. Burnett, M. Shou, C. Lee, S. Barr, S. Fuchs, Stephen E. Epstein. Circulation, 2004

1,334 citations recorded by the source corpus.

Subfields: Genetics, Rehabilitation, Surgery

View Paper: https://www.semanticscholar.org/paper/6203c2b8d9e37aff9ea32b006f2998dfafe9ca3c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. A. Caplan
2. L. Meirelles
3. Maria Ester Bernardo
4. W. Fibbe

In Rehabilitation

1. Liwen Chen
2. Yaojiong Wu
3. E. Tredget
4. W. Fibbe
5. Maria Ester Bernardo

In Surgery

1. A. Caplan

Citations in the corpus

• Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma (2006, background): “Our fi ndings are particularly surprising in light of the demonstrated proangiogenic eff ects of MSCs in ischemic tissue (29, 52, 53).”
• Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. (2005, background): “Moreover, recent studies suggest that monocytic cells as well as mesenchymal stem cells augment arteriogenesis via the release of angiogenic growth factors [20–22].”
• Paracrine Factors of Mesenchymal Stem Cells Recruit Macrophages and Endothelial Lineage Cells and Enhance Wound Healing (2008, positive): “Real-Time PCR analysis of expression levels of growth factors and chemokines in BM-MSCs and dermal fibroblasts treated under hypoxic conditions revealed that BM-MSCs expressed significantly greater amounts of several growth factors including epidermal growth factor (EGF, 15 fold), keratinocyte growt”
• Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. (2007, background): “While the predominant belief was that improvement in outcome following organ injury and stem cell administration was the result of replacing damaged cells by differentiated stem cells, we and other groups have shown that paracrine mechanisms are primarily responsible for the organprotective actions ”
• The secretion profile of mesenchymal stem cells and potential applications in treating human diseases (2022, background): “The superiority of MSCs in promoting wound healing mainly results from a series of mitogenic and vascular trophic factors, including angiogenic factors to restore the blood supply in ischemia tissues.(125) It has been confirmed that growth factors (VEGF, HGF, and IGF-1) are rich in MSC culture mediu”
• Mechanisms involved in the therapeutic properties of mesenchymal stem cells. (2009, background): “The pro-angiogenic effect of MSCs has been demonstrated in a murine model of hind limb ischemia [89].”