Deconvoluting the context-dependent role for autophagy in cancer

By E. White. Nature Reviews. Cancer, 2012

1,671 citations recorded by the source corpus.

Autophagy (also known as macroautophagy) captures intracellular components in autophagosomes and delivers them to lysosomes, where they are degraded and recycled. Autophagy can have two functions in cancer. It can be tumour suppressive through the elimination of oncogenic protein substrates, toxic unfolded proteins and damaged organelles. Alternatively, it can be tumour promoting in established cancers through autophagy-mediated intracellular recycling that provides substrates for metabolism and that maintains the functional pool of mitochondria. Therefore, defining the context-specific role for autophagy in cancer and the mechanisms involved will be important to guide autophagy-based therapeutic intervention.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/61d007acbce79cb086b51fce3f7e9b8da9d05131

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

In Molecular Biology

Citations in the corpus

Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. (2013, background): “Of note, autophagy is frequently disabled during early oncogenesis (Morselli et al., 2009; White, 2012), perhaps helping incipient tumors to evade immunosurveillance.”
Autophagy, Metabolism, and Cancer (2015, positive): “Chronic liver damage is a known tumor promoter by inducing hepatocyte death and activation of Kupffer cells and cytokine production that stimulates compensatoryproliferation (16).”
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy (2014, background): “Selective autophagy may be particularly important for the survival or growth of particular cancer cell types 7,8 but in other contexts may act as a tumor suppressor to maintain normal cellular homeostasis and constrain tumor initiation 9,10 .”
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. (2013, background): “…in the M oxidative-stress response, metabolic pathways, and innate immunity, and dysregulation of these processes is associated with pathogenic mechanisms of multiple human diseases, including tumor development (Kensler et al., 2007; Rubinsztein et al., 2011; Sporn and Liby, 2012; White, 2012).”
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “For a more detailed review on autophagy in cancer we refer interested readers to White (2012).”
Autophagy and autophagy-related proteins in cancer (2020, background): “and development, finally promotes tumorigenesis and causes resistance to therapeutic agents [180, 182, 186].”
The Roles of Autophagy in Cancer (2018, background): “In addition, many studies suggest that autophagy has been linked to both cancer initiation and cancer therapy for several years [4,5].”