The Notch signalling system: recent insights into the complexity of a conserved pathway
By K. G. Guruharsha, Mark W. Kankel, S. Artavanis-Tsakonas. Nature reviews genetics, 2012
712 citations recorded by the source corpus.
Notch signalling links the fate of one cell to that of an immediate neighbour and consequently controls differentiation, proliferation and apoptotic events in multiple metazoan tissues. Perturbations in this pathway activity have been linked to several human genetic disorders and cancers. Recent genome-scale studies in Drosophila melanogaster have revealed an extraordinarily complex network of genes that can affect Notch activity. This highly interconnected network contrasts our traditional view of the Notch pathway as a simple linear sequence of events. Although we now have an unprecedented insight into the way in which such a fundamental signalling mechanism is controlled by the genome, we are faced with serious challenges in analysing the underlying molecular mechanisms of Notch signal control.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/61a33f270c2f4fbe104cd8425cb793fd37d45a96
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Citations in the corpus
- Transcriptional Regulation by Hypoxia Inducible Factors (2013, background): “Both HIF and Notch signaling are known to inhibit differentiation of certain cell types (Fortini, 2009; Guruharsha et al., 2012) and several lines of evidence suggest that they are able to work together.”
- Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974 (2013, background): “The cellular function of DTX3L in the mammalian Notch pathway is not clear, but its Drosophila homolog Deltex is a positive regulator of Notch signaling in Drosophila (34).”
- A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes (2016, background): “So far, a two-step ‘on and off‘ model of Notch dependent transcription has been proposed (4–6 , 17).”