Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles.

By Fang Lu, Si-Han Wu, Y. Hung, C. Mou. Small, 2009

982 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The nanosilica hazard: another variable entity (2010, background): “Amorphous (mesoporous) 30, 50, 110, 170 and 280 nm • Synthesis, suspension stability (no interparticle aggregation), hydrodynamic diamaters, zeta potential HeLa • MTT • onfocal laser scanning microscopy • ICP-MS • Cellular uptake is highly particle size-dependent (with the optimum size of 50 nm); li”
Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. (2010, background): “However, previous investigations on the effects of particle size and surface charge gave little consideration to independently alter one variable at a time while monitor the effect of each variable [2,10].”
Sol-gel based materials for biomedical applications (2016, background): “[96] demonstrated that the particle sizes of MSNs were controlled over a wide range, from 30 to 280 nm, by simply adjusting the pH value of the precursor solutions.”
The effect of nanoparticle size, shape, and surface chemistry on biological systems. (2012, background): “For spherical gold nanoparticles, silica nanoparticles, single-walled carbon nanotubes, and quantum dots, a 50-nm diameter is optimal to maximize the rate of uptake and intracellular concentration in certain mammalian cells (14, 16, 17).”