Depression and immune function: central pathways to morbidity and mortality.

By J. Kiecolt-Glaser, R. Glaser. Journal of Psychosomatic Research, 2002

603 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Cardiology and Cardiovascular Medicine, Immunology

View Paper: https://www.semanticscholar.org/paper/615f9f036b7b2469b67f1c26398ce1e882eef990

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

In Cardiology and Cardiovascular Medicine

In Immunology

Citations in the corpus

Social Relationships and Health Behavior Across Life Course (2010, background): “…well as stress that contributes to psychological distress, which, in turn, is associated with increased physiological arousal (e.g., heart rate, stress hormones) that elicits behavioral coping responses and with greater propensities for unhealthy behavior in general (Kiecolt-Glaser & Glaser 2002).”
Diabetes, depression, and quality of life: a population study. (2004, background): “Various mechanisms have been proposed for this, including changes to the immune system ( 24 ).”
Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis (2009, background): “Increased HPA activity can lead to elevated cortisol levels, which are known to initiate and/or worsen symptoms of depression (80).”
Cytokine, Sickness Behavior, and Depression (2009, background): “At the clinical level, there is growing evidence that major depression is associated with significant elevations in circulating levels of proinflammatory cytokines, in particular IL-6 [63], [64], [65], [66], [67], [68].”
Brain mediators of cardiovascular responses to social threat, Part I: Reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity (2009, background): “, 1992) and impairments in declarative memory (McEwen and Sapolsky, 1995), promote proinflammatory immune responses (Kiecolt-Glaser and Glaser, 2002), and contribute to cognitive and physical aging (Mcewen, 2007), among other adverse effects.”
Inflammation-Associated Depression: From Serotonin to Kynurenine (2010, background): “This is the case in patients with coronary heart disease (Frasure-Smith et al., 2007; Joynt et al., 2003; Kiecolt-Glaser and Glaser, 2002; Lesperance and Frasure-Smith, 2007).”
Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis (2006, neutral): “Both depression and type 2 diabetes are found to be associated with increased Creactive protein, TNF-α and proinflammatory cytokines, including IL-6 [38–42].”
The epidemiology of depression across cultures (2013, background): “These include a variety of poor health behaviors known to be linked to MDD, such as elevated rates of smoking and drinking (30), obesity (23), low compliance with treatment regimens (111, 146), and a variety of biological dysregulations, such as hypothalamic-pituitary-adrenal hyperactivity and impai”
β-Adrenergic Receptor Antagonism Prevents Anxiety-like Behavior and Microglial Reactivity Induced by Repeated Social Defeat (2011, background): “These stressor-induced pathways have a profound influence on behavior, immunity, and physiology in both humans and rodents (Blanchard et al., 2001; Kiecolt-Glaser and Glaser, 2002; Kinsey et al., 2007; Cole et al., 2010).”