Melanopsin (Opn4) Requirement for Normal Light-Induced Circadian Phase Shifting

By Satchidananda Panda, Trey K. Sato, A. M. Castrucci, M. Rollag, W. J. DeGrip, John B. Hogenesch, I. Provencio, Steve A. Kay. Science, 2002

874 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/61229c26099643e5dd0b04ec85d067dabca30259

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Endocrine and Autonomic Systems

In Plant Science

Citations in the corpus

The diversity of temporal niches in mammals (2008, background): “The mammalian circadian system can acquire information about illuminance levels in the environment both through classical photoreceptors and through photosensitive ganglion cells that use melanopsin as a photopigment (Hattar et al. 2002; Panda et al. 2002; Ruby et al. 2002a; Gooley et al. 2003; Qiu ”
The circadian clock: pacemaker and tumour suppressor (2003, background): “Light signals are received by a subset of MELANOPSIN-EXPRESSING RETINAL GANGLION CELLS , and are transmitted directly to the SCN through the retinohypothalamic tract (RHT”
Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in mice (2003, background): “, light-induced phase delays of the circadian cloc”
Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision (2010, background): “The ipRGCs mediate a variety of physiological responses to ambient light, such as circadian photoentrainment and the pupillary light reflex (Guler et al., 2008; Hatori et al., 2008; Lucas et al., 2003; Panda et al., 2002; Ruby et al., 2002).”
Physiology of circadian entrainment. (2010, background): “Many of the deficits in these responses were subtle or not apparent in melanopsin-null mice (291, 350, 380, 419).”
Central projections of melanopsin‐expressing retinal ganglion cells in the mouse (2006, background): “Electrophysiological and behavioral evidence strongly suggests that conventional rod and cone photoreceptors can drive SCN unit responses and circadian phase shifts (Aggelopoulos and Meissl, 2000; Panda et al, 2002, 2003; Ruby et al., 2002; Lucas et al., 2003; Hattar et al, 2003).”
A clockwork web: circadian timing in brain and periphery, in health and disease (2003, background): “Knock-out of the melanopsin gene in mice attenuates circadian and other subliminal responses to light in vivo”
Epidemiology of the human circadian clock. (2007, background): “Unlike many other animals, the zeitgeber light is detected exclusively by the eyes in mammals, by a combination of rods, cones, and a recently discovered additional retinal photopigment, melanopsin, which is found to be dispersed in the ganglion cell layer.(2,3) The retinal signals are transduced to”