Model-based lesion mapping of cognitive control using the Wisconsin Card Sorting Test
By Jan Gläscher, Ralph Adolphs, Daniel Tranel. 2019
60 citations recorded by the source corpus.
The role of the frontal lobes in cognition and behavior has long been enigmatic. Over the past decade, computational models have provided a powerful approach to understanding cognition and decision-making. Here, we used a model-based approach to analyze data from a classical task used to assess frontal lobe function, the Wisconsin Card Sorting Test. We applied computational modeling and voxel-based lesion-symptom mapping in 328 patients with focal lesions, to uncover cognitive processes and neural correlates of test scores. Our results reveal that lesions in the right prefrontal cortex are associated with elevated perseverative errors and reductions in the model parameter of sensitivity to punishment. These findings indicate that the capacity to flexibly switch between task sets requires the detection of contingency changes, which are enabled by a sensitivity to punishment that reduces perseverative errors. We demonstrate the power of model-based approaches in understanding patterns of deficits on classical neuropsychological tasks. The frontal cortex is involved in cognitive control, e.g. cognitive flexibility and behavioral inhibition, but the roles of frontal subdivisions are unclear. Here, the authors used computational modelling of cognitive control task performance to map lesions responsible for impairments in specific cognitive operations.
Subfields: Cognitive Neuroscience
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In Cognitive Neuroscience
- K. Tye
- Ben Tsuda
- Terrence J. Sejnowski
- Hava T. Siegelmann
- Yoshua Bengio
- Laurenz Wiskott
- J. Urgen Schmidhuber
- Scott Makeig
Citations in the corpus
- A modeling framework for adaptive lifelong learning with transfer and savings through gating in the prefrontal cortex (2020, background): “Patients with prefrontal damage often have difficulty with this task, with some stereotypically making perseveration errors, indicating an inability to switch rules when given reinforcement [4],[5].”