Major Dissociation Between Medial and Lateral Entorhinal Input to Dorsal Hippocampus

By E. Hargreaves, Geeta Rao, Inah Lee, James J. Knierim. Science, 2005

671 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/60d6bf2fc3ff48ee6307f1e859abd668284175e7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Representation of Non-Spatial and Spatial Information in the Lateral Entorhinal Cortex (2011, background): “) As expected, MEC neurons showed a number of units with spatially selective responses (Figure 3C), and the distribution of spatial information scores (Figure 3A) resembled the distributions from previous studies (Hargreaves et al., 2005; Yoganarasimha et al., 2010).”
The hippocampus and related neocortical structures in memory transformation. (2018, background): “As with regard to aHPC and pHPC, there are at least two pathways in entorhinal cortex, the medial carrying spatial information and the lateral carrying object information, that may in ﬂ uence both transformation, and encoding and retrieval processes [163,164].”
Computational influence of adult neurogenesis on memory encoding. (2009, positive): “For instance, although the spatial properties of mEC neurons have been well characterized (Hafting et al., 2005), the structure of the lEC input to the DG remains unclear (Hargreaves et al., 2005).”
Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop (2009, background): “Finally, the role of the lateral EC, another major input to the hippocampus, in the temporal coordination of hippocampal neurons (Hargreaves et al., 2005) should also be addressed.”
Place cells, grid cells, and the brain's spatial representation system. (2008, background): “The MEC also interacts closely with the lateral entorhinal cortex, where cells apparently do not show spatial modulation (Hargreaves et al. 2005).”
An analysis of dentate gyrus function (an update) (2017, background): “, objects, odors) information are mediated by opioid receptors [2,3].”
Report Traces of Experience in the Lateral Entorhinal Cortex (2013, positive): “LEC neurons show little spatial modulation when rats run in empty open-field environments [6, 7] but fire in the vicinity of discrete objects [7], suggesting that they provide information about the specific content of the spatial environment.”
Coordinated memory replay in the visual cortex and hippocampus during sleep (2007, background): “Place-specific firing has also been reported in the medial entorhinal corte”
Impaired spatial representation in CA1 after lesion of direct input from entorhinal cortex. (2008, background): “…dynamic representations of place are computed in the entorhinal cortex and associated cortical areas (Fyhn et al., 2004, 2007; Hafting et al., 2005; Hargreaves et al., 2005; Sargolini et al., 2006) and that the hippocampus instead integrates the output from the spatial map in the entorhinal cortex…”
Conflicts between Local and Global Spatial Frameworks Dissociate Neural Representations of the Lateral and Medial Entorhinal Cortex (2013, background): “7B), suggesting that the spatially nonspecific LEC representations (Hargreaves et al., 2005; Yoganarasimha et al., 2011) showed considerable variability from one session to the next, even in the STD 1 versus STD 2 comparisons (but see next paragraph).”