Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
By Anjali P. Kusumbe, Saravana K. Ramasamy, R. Adams. Nature, 2014
1,913 citations recorded by the source corpus.
The mammalian skeletal system harbours a hierarchical system of mesenchymal stem cells, osteoprogenitors and osteoblasts sustaining lifelong bone formation. Osteogenesis is indispensable for the homeostatic renewal of bone as well as regenerative fracture healing, but these processes frequently decline in ageing organisms, leading to loss of bone mass and increased fracture incidence. Evidence indicates that the growth of blood vessels in bone and osteogenesis are coupled, but relatively little is known about the underlying cellular and molecular mechanisms. Here we identify a new capillary subtype in the murine skeletal system with distinct morphological, molecular and functional properties. These vessels are found in specific locations, mediate growth of the bone vasculature, generate distinct metabolic and molecular microenvironments, maintain perivascular osteoprogenitors and couple angiogenesis to osteogenesis. The abundance of these vessels and associated osteoprogenitors was strongly reduced in bone from aged animals, and pharmacological reversal of this decline allowed the restoration of bone mass.
Subfields: Cancer Research, Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/60a2b1d6d26d5b7fd7983245e22fb23ce4a2ad21
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Citations in the corpus
- Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology (2017, background): “Adult bone capillaries can be divided into two types, H and L, on the basis of their marker expression and function (136) (Fig.”
- Thalidomide‐induced teratogenesis: History and mechanisms (2015, background): “Moreover, changes in vessel patterns could have an impact on chrondrogenesis, which requires a specialized vasculature to allow bone growth and remodeling (Kusumbe et al., 2014; Ramasamy et al., 2014).”
- Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration (2017, background): “…these functionally distinct cell populations and a preferential association of perivascular multipotent and adipogenic cells to L type vessels, while the distribution of endosteal osteogenic cells resembles more closely localizations of H type endothelium (Itkin et al., 2016; Kusumbe et al., 2014).”