Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade.

By M. Sanders, P. Grondin, B. Hegarty, M. A. Snowden, David Carling. Biochemical Journal, 2007

702 citations recorded by the source corpus.

Subfields: Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/6086a8626077e545939ff3c736cf27bcbb55d6d4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. David M. Sabatini
2. D. Hardie
3. R. Shaw
4. Timothy R. Peterson
5. J. Villén
6. Shomit Sengupta
7. David Carling
8. Steven P. Gygi

In Surgery

1. R. Shaw
2. David M. Sabatini
3. D. Hardie
4. David Carling
5. L. Hue
6. H. Taegtmeyer
7. S. Hawley
8. G. Steinberg

Citations in the corpus

• Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress (2010, background): “Molecular C a conformation that allows the kinase subunit to be phosphorylated by the upstream activating kinase LKB1 (Sanders et al., 2007), thus slowing cell growth and its many ATP-consuming processes (Shaw, 2009).”
• AMP-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype (2008, unknown): “Although the LKB1 complex phosphorylates AMPK in response to changes in the AMP/ATP ratio (6), CAMKK phosphorylates AMPK in response to an increase in intracellular Ca(2) level (5).”
• AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy (2007, background): “, recent work suggests that it works entirely by inhibiting the dephosphorylation of Thr172, probably catalysed by a form of protein phosphatase-2”
• Abscisic acid dynamics, signaling and functions in plants. (2019, background): “Protein phosphatases can interact with and inhibit SnRK2, SnRK1, SnRK3 and even mammalian AMPKs, which are also core components in abiotic stress, ABA and energy signaling (Sanders et al. 2007; Zhu 2016).”
• Structure of Mammalian AMPK and its regulation by ADP (2011, methodology): “The position of the phosphorylated Thr-172 residue is indicated.”
• An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. (2007, background): “AMP also contributes to AMPK activation by reducing the dephosphorylation of the catalytic a subunit [14].”