CD95 Signaling via Ceramide-rich Membrane Rafts*
By H. Grassmé, A. Jekle, Andrea Riehle, H. Schwarz, J. Berger, K. Sandhoff, R. Kolesnick, E. Gulbins. Journal of Biological Chemistry, 2001
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Clustering seems to be employed by many receptors for transmembrane signaling. Here, we show that acid sphingomyelinase (ASM)-released ceramide is essential for clustering of CD95.In vitro and in vivo, extracellularly orientated ceramide, released upon CD95-triggered translocation of ASM to the plasma membrane outer surface, enabled clustering of CD95 in sphingolipid-rich membrane rafts and apoptosis induction. Whereas ASM deficiency, destruction of rafts, or neutralization of surface ceramide prevented CD95 clustering and apoptosis, natural ceramide only rescued ASM-deficient cells. The data suggest CD95-mediated clustering by ceramide is prerequisite for signaling and death.
Subfields: Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/604b5a8981a2819085decae3f86c74fa480cd183
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Citations in the corpus
- The CD95(APO-1/Fas) DISC and beyond (2003, background): “Other studies have implicated the involvement of ceramide released by acid sphingomyelinase, enriched in lipid rafts in the clustering of CD95 and subsequent apoptosis.(105) It was also shown that ceramide is essential for the efficient signaling of CD95 and that signaling is preceded by capping of ”