Synthetic Mammalian Prions

By G. Legname, I. Baskakov, Hoang-Oanh B. Nguyen, D. Riesner, Fred E. Cohen, S. DeArmond, S. Prusiner. Science, 2004

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The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease (2012, background): “Moreover, bona fide synthetic mammalian prions can adopt amyloid and non-amyloid forms (Colby et al., 2009, 2010; Legname et al., 2004; Piro et al., 2011).”
In vitro generation of infectious scrapie prions. (2005, methodology): “(May et al., 2004; Soto and Castilla, with excess PrP C to enlarge the PrP res aggregates that are then sonicated to generate multiple smaller units 2004; Legname et al., 2004).”
Pathogenic Protein Seeding in Alzheimer’s Disease and Other Neurodegenerative Disorders (2011, result): “The failure of seeding by synthetic Ab was not unanticipated, in that the induction of prion disease also has been difficult to achieve with PrP generated in vitro.(57) It is possible that the aggregation of synthetic Ab under suitable (but as yet undefined) conditions will yield a more effective in”
Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs (2004, background): “Recently, in vitro production of recombinant mouse PrP SC capable of disease transmission provided compelling evidence that prions are the infectious protei”