Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells.

By M. Dusseaux, Emmanuel Martin, Nacer-Eddine Serriari, I. Peguillet, V. Prémel, D. Louis, M. Milder, L. Le Bourhis, C. Soudais, E. Treiner and 1 more. Blood, 2011

973 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/5ff95b3c65451157ce3ba19cbd558d6b75f96d1e

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In Immunology

1. D. Brenner
2. Y. Bryceson

Citations in the corpus

• Liver inflammation and fibrosis. (2017, background): “MAIT cells are highly enriched in the human liver, representing 20% to 50% of intrahepatic T cells (83).”
• CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin (2017, positive): “Unconventional mucosal- associated invariant T (MAIT) cells represent a fraction of pe- ripheral blood IL-17-producing T cells (Dusseaux et al., 2011).”
• IL‐12 and IL‐7 synergize to control mucosal‐associated invariant T‐cell cytotoxic responses to bacterial infection (2017, background): “104 Upon activation, MAIT cells rapidly express effector cytokines such as TNFα, IFNγ and IL105 17[24][25] and are also able to inhibit intracellular bacterial growth within infected 106 macrophages [26].”