Functional biology of the α 2 δ subunits of voltage-gated calcium channels

By A. Davies, J. Hendrich, AT Van Minh, J. Wratten, L. Douglas, A. Dolphin. 2007

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Voltage-gated calcium channels. (2011, background): “Genes encoding four a2d subunits have been described (Klugbauer et al. 1999), and the a2d isoforms produced by these different genes have selective effects on the level of functional expression and the voltage dependence of different a1 subunits (Davies et al. 2007).”
The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential (2015, background): “Acute effects of gabapentinoid drugs to inhibit transmitter release and synaptic transmission have been observed in some, but not all, in vitro systems (reviewed in Davies et al., 2007; Taylor et al., 2007).”
G protein inhibition of CaV2 calcium channels (2010, background): “The α 2 component is extracellular and until recently it was considered that δ traversed the membrane giving rise to a type I transmembrane topology.(10,11) However, in contrast to this assumption, recent evidence suggests that α 2 δ”
Cellular and Molecular Mechanisms of Pain (2009, unknown): “Indeed, this subunit is the target of the gabapentinoid class of anticonvulsants, which are now widely used to treat neuropathic pain (Davies et al., 2007).”