A decade of caspases
By Alexei Degterev, M. Boyce, Junying Yuan. Oncogene, 2003
1,177 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/5f9f7787916943ab42311b2d08a09fa08f6e7ed1
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In Immunology
In Molecular Biology
Citations in the corpus
- Cellular Stress Responses: Cell Survival and Cell Death (2010, background): “Caspases, a family of cysteine proteases, act as common death effector molecules in various forms of apoptosis [25].”
- Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies (2016, background): “The activation of initiator caspases results in the processing of the downstream effector caspases-3, -6 and -7 whose activation leads to the cleavage of essential substrates for cell viability, inducing cell death (Figure 1) [17].”
- Caspases in apoptosis and beyond (2008, background): “The S4 subsite provides major specificity-conferring elements to different caspases (Degterev et al., 2003; Schweizer et al., 2003).”
- A guide to cell death pathways (2023, positive): “The genomes of mammals encode multiple caspases (the mouse genome encodes 11 caspases; the human genome encodes 13 caspases), which mediate cell death as well as inflammation 99 .”
- Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy (2006, background): “Proteolytic enzymes such as caspases are important effector molecules in apoptosis (Degterev et al., 2003).”
- Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion (2008, background): “flexneri-induced macrophage death depends on caspase-1 but not other caspases, such as caspase-3, an “executioner” of cell death, or caspase-11, an activator of caspase-1 in response to LPS challenge (50, 109, 324).”