RNA recognition motifs: boring? Not quite.
By A. Cléry, M. Blatter, F. Allain. Current Opinion in Structural Biology, 2008
632 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/2866591ed451bf535aced8dab0528b2bcd3a645f
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Stanley Fields
- David L. Young
- Christina R. Miller
- Daniel Melamed
- Caitlin E. Gamble
- Blaz Zupan
- Thomas Tuschl
- Gene W. Yeo
Citations in the corpus
- How RNA binding proteins interact with RNA: molecules and mechanisms (2020, background): “Each RRM has its own sequence preferences, often for degenerate sequences such as GU-rich tracts (Cléry et al., 2008).”
- A census of human RNA-binding proteins (2014, background): “1 Canonical RNA-binding domains Domain Description RRM RNA recognition motif, single-strand RNA (ssRNA)-binding (Cléry et al., 2008) KH KH-homology domain, ssRNA-binding (Grishin, 2001; Lunde et al.”
- Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein (2013, background): “A typical RRM folds into a four-stranded antiparallel β sheet, packed against two α helices, with RNA binding usually achieved by contacts made between the β sheet surface and a single-stranded RNA (Maris et al. 2005; Clery et al. 2008; Muto and Yokoyama 2012).”
- Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis (2019, background): “Some RBPs, such as TDP-43, are also implicated in neurodegenerative diseases which therefore hints of disturbances in the RNA metabolism as a causative factor (Maris et al., 2005; Lunde et al., 2007; Clery et al., 2008).”
- RBPDB: a database of RNA-binding specificities (2010, methodology): “Most proteins were selected based on the presence of known sequence-specific RBDs (Table 1), which we compiled from review papers (3,4,7,8) and from searching and scanning Pfam domain annotations (27).”
- Characterising the RNA targets and position-dependent splicing regulation by TDP-43; implications for neurodegenerative diseases (2011, background): “As a single RRM domain generally recognizes four nucleotide”