The significance of cancer cell expression of the chemokine receptor CXCR4.
By F. Balkwill. Seminars in Cancer Biology, 2004
811 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/5f6d256dcb0fe389c83ec15df982d759ebc3c58c
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- Jo Vandercappellen
- J. Van Damme
- J. Condeelis
- Jianhua Wang
- J. Benovic
- E. Roussos
- Marcello Maggiolini
- S. Struyf
In Oncology
- Jo Vandercappellen
- J. Van Damme
- J. Condeelis
- Jianhua Wang
- J. Benovic
- E. Roussos
- Marcello Maggiolini
- R. Taichman
Citations in the corpus
- CXCL12/CXCR4/CXCR7 Chemokine Axis and Cancer Progression (2010, background): “In ovarian cancer, CXCR4 is a dominant chemokine receptor in cancer tissues [100].”
- G protein-coupled receptors: novel targets for drug discovery in cancer (2010, background): “The CXC chemokine CXCL12 (also known as stromal cell-derived factor 1α (SDF1α)), which is a growth regulator and stimulator of angiogenic factors in cancer cells, is an additional example of a GPCR ligand that can induce the EGFR transduction cascade, this time through the activation of the cognate ”
- International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “It is also functionally expressed by many cancer cells of hematopoietic and nonhematopoietic origin (Balkwill, 2004).”
- Chemotaxis in cancer (2011, background): “One of the most widely studied examples is the chemokine receptor CXCR4 and its ligand CXCL12 (also known as SDF1), which have been found to initiate both single cell and multicellular directed migration during metastatic progression in 11 different types of cance”
- Regulation of CXCR4 signaling. (2007, background): “The expression of CXCR4 has been detected in 23 different cancers of various origins [131] and is the most common chemokine receptor expressed on cancer cells [23].”
- The role of CXC chemokines and their receptors in cancer. (2008, background): “[143] F.”