Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator Activity by IκB Kinase

By R. Wu, J. Qin, Y. Hashimoto, J. Wong, Jianming Xu, S. Tsai, M. Tsai, B. O’Malley. Molecular and Cellular Biology, 2002

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Mechanisms of tamoxifen resistance. (2004, background): “These effects are most likely to be achieved by the phosphorylation of co-regulators, which may in turn effect their nuclear sublocalisation (Hong & Privalsky 2000, Wu et al. 2002).”
IκB Kinase α-Mediated Derepression of SMRT Potentiates Acetylation of RelA/p65 by p300 (2006, background): “Unlike IKK , IKK has distinct functions as a nuclear kinase capable of phosphorylating SRC-3 (66), CBP (67), histone H3, and the SMRT corepressor (4, 5, 26, 67), events linked to transcriptional activation of both NF- B-regulated and non-NF- B-regulated gene targets (4, 5, 26, 47).”
Coregulator function: a key to understanding tissue specificity of selective receptor modulators. (2004, background): “Moreover, SRC-3 is found as a complex with I B kinase (IKK), the kinase responsible for phosphorylation and subsequent degradation of I B and consequently the activation of nuclear factor- B (NF- B); IKK complexes can phosphorylate SRC-3 in vitro (222).”