Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics

By S. Grüsser, Jana Wrase, Sabine Klein, D. Hermann, M. Smolka, M. Ruf, W. Weber-Fahr, Herta Flor, K. Mann, D. Braus and 1 more. Psychopharmacology, 2004

606 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Epidemiology, Neurology

View Paper: https://www.semanticscholar.org/paper/5f2a2969c377caed38059d3052d492e2beab6d66

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Nora D. Volkow
2. Antoine Bechara
3. Rita Z. Goldstein
4. James E. Cox
5. Edwin W. Cook III
6. Rosalyn E. Weller
7. Brian Knutson
8. Hugh Garavan

In Epidemiology

1. Nora D. Volkow
2. Antoine Bechara
3. Hugh Garavan
4. Rita Z. Goldstein
5. Martin P. Paulus
6. Gene-Jack Wang
7. Daria J. Kuss
8. Mark D. Griffiths

In Neurology

1. Felix Bermpohl
2. Nora D. Volkow
3. Brian Knutson
4. Hugh Garavan
5. R. Spanagel
6. A. Craig

Citations in the corpus

• fMRI Reactivity to High-Calorie Food Pictures Predicts Short- and Long-Term Outcome in a Weight-Loss Program (2012, background): “In addition, greater activation to alcoholrelated visual cues in the putamen (as well as ACC) was predictive of relapse in abstinent alcoholics (Grüsser et al., 2004).”
• Functional magnetic resonance imaging of reward prediction (2005, background): “For instance, onestudy illustrated that putamen,anterior cingulate, and MPFC activation to alcohol cues predicted speed of relapse in a sample of alcoholics [ 50 ].”
• The Neurocircuitry of Impaired Insight in Drug Addiction (2009, positive): “Anterior cingulate cortex activation levels have also been shown to be predictive of successful treatment outcome in alcoholics and methamphetamine users [ 47 ,48] and can be improved by acute cocaine administration [49] (this restorative effect is likely to be dose-specific [50]) in cocaine users.”
• Alcoholism: a systems approach from molecular physiology to addictive behavior. (2009, background): “Cue-induced activation of these brain areas appears to be most pronounced in subjects who subsequently relapse during a 3-mo follow-up period (169), suggesting that fMRI may help to identify a group of alcohol-dependent subjects with an otherwise undetected high risk of relapse.”
• Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics (2007, background): “This process may be mediated by recruitment of circuitr yi nnervated by midbrain dopamine neurons, since presentation of alcohol-associated stimuli elicits increased activation of the striatum, anterior cingulate cortex (ACC), amygdala, and medial prefrontal cortex (mPFC) in alcoholics, relative to ”