Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
By P. Thaker, Liz Y. Han, Aparna A. Kamat, Jesusa Arevalo, R. Takahashi, Chunhua Lu, Nicholas B. Jennings, G. Armaiz-Pena, J. Bankson, Murali K. Ravoori and 17 more. Nature Medicine, 2006
1,286 citations recorded by the source corpus.
Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/5ed9ec50cbe53add3d6ffdfc88e3619837aa9a32
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Behavioral Neuroscience
- John T. Cacioppo
- Louise C. Hawkley
- Steve W. Cole
- Gregory E. Miller
- E. Chen
- Michael R. Irwin
- George M. Slavich
- M. Del Giudice
In Cellular and Molecular Neuroscience
In Psychiatry and Mental health
Citations in the corpus
- Social regulation of gene expression in human leukocytes (2007, background): “This study's identification of a plausible neuroendocrine mediator of transcriptional alteration (GR signaling), which is known to relate to social phenotype in humans [27-30] and is causally impacted by experimental social isolation in animal models [11-14], is consistent with social influences on ”
- Health psychology: developing biologically plausible models linking the social world and physical health. (2009, background): “F or p er so na l u se o nl y. ANRV364-PS60-19 ARI 24 November 2008 18:54 begun to accelerate mechanistic analyses of biobehavioral relationships in cancer (Antoni et al. 2006, Thaker et al. 2006).”
- Molecular Pathways: Beta-Adrenergic Signaling in Cancer (2011, background): “by tumor cells (28–30) and immune cells (29), VEGFmediated increases in angiogenesis (27, 31, 32), matrix metalloproteinase (MMP)–related increases in tissue inva-”
- The seed and soil hypothesis revisited - the role of tumor-stroma interactions in metastasis to different organs (2011, background): “model of ovarian cancer, the increased levels of catecholamines resulting from chronic behavioral stress were found to signal for an increase in the tumor vascular surface area, which led to a significant increase in peritoneal metastases.(56) Similarly, in a breast cancer model, stress-induced Sp e”
- Depression as a predictor of disease progression and mortality in cancer patients (2009, result): “It is rather surprising that depression is shown to predict mortality but not disease recurrence, especially given that research based on animal models clearly demonstrated the effect of stress on metastasis and tumor growth.(4) We postulate that this difference is primarily due to the limited numbe”
- Inflammation: The Common Pathway of Stress-Related Diseases (2017, background): “Chronic stress is thought to correlate with the etiology of tumor growth, progression and metastasis (Thaker et al., 2006).”
- Autonomic Nerve Development Contributes to Prostate Cancer Progression (2013, background): “Recent studies have revealed that the SNS, a major pathway for stress-induced signals, enhances tumor growth through the b2-adrenergic receptor (Adrb2) expressed on tumor cells (7, 19) and also regulates the hematopoietic stem cell niche in the bone marrow via Adrb2 and Adrb3 expressed in the stroma”
- siRNA delivery systems for cancer treatment. (2009, methodology): “Neutral DOPC-based liposomes have been used for intraperitoneal delivery of siRNAs targeting focal-adhesion-kinase [53], β-2 adrenergic receptor [113], and interluekin-8 [55] in an ovarian cancer mouse model.”