Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.

By S. Szabo, B. Sullivan, Claudia Stemmann, A. Satoskar, B. Sleckman, Laurie H. Glimcher. Science, 2002

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Inflammatory Cytokines as a Third Signal for T Cell Activation (2010, unknown): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript transcription factors, several of which are known to play important roles in CD8 T cell differentiation including T-bet [29,30], eomesodermin [31] and Blimp-1 [32-35].”
The cytokine network in asthma and chronic obstructive pulmonary disease. (2008, background): “STAT1, resulting in expression of genes encoding Th1 cytokines and suppression of genes encoding Th2 cytokines (26).”
Peripheral CD4 T cell differentiation regulated by networks of cytokines and transcription factors (2010, background): “T-bet deficient (Tbx21 ⁄ ) cells produce diminished but measurable amounts of IFNc during in vitro culture and in in vivo responses to Leishmania major infection (48).”
Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells (2010, background): “However, CpG stimuli did not enhance T-bet expression, unless exogenous IL-12 was also provided (Joshi et al., 2007; Szabo et al., 2002).”