The enigmatic mossy cell of the dentate gyrus

By H. Scharfman. 2016

249 citations recorded by the source corpus.

Mossy cells comprise a large fraction of the cells in the hippocampal dentate gyrus, suggesting that their function in this region is important. They are vulnerable to ischaemia, traumatic brain injury and seizures, and their loss could contribute to dentate gyrus dysfunction in such conditions. Mossy cell function has been unclear because these cells innervate both glutamatergic and GABAergic neurons within the dentate gyrus, contributing to a complex circuitry. It has also been difficult to directly and selectively manipulate mossy cells to study their function. In light of the new data generated using methods to preferentially eliminate or activate mossy cells in mice, it is timely to ask whether mossy cells have become any less enigmatic than they were in the past.

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Citations in the corpus

Re-evaluating circuit mechanisms underlying pattern separation (2019, neutral): “Ascending mossy cell axons project to the molecular layer where they contact granule cell dendrites, while collaterals are thought to innervate local inhibitory interneurons in the hilus (Scharfman, 2016).”
An analysis of dentate gyrus function (an update) (2017, unknown): “For a more detailed description see [4,5].”
In vivo imaging of dentate gyrus mossy cells in behaving mice (2017, background): “The polymorphic hilar region of the DG, however, also contains another major glutamatergic principal cell type, mossy cells (MCs) (Amaral, 1978; Scharfman, 2016), which”