In vivo imaging of dentate gyrus mossy cells in behaving mice

By Nathan B Danielson, G. Turi, Max A. Ladow, Spyridon Chavlis, Panagiotis C. Petrantonakis, Panayiota Poirazi, Attila Losonczy. 2017

169 citations recorded by the source corpus.

Summary Mossy cells in the hilus of the dentate gyrus constitute a major excitatory principal cell type in the mammalian hippocampus, however, it remains unknown how these cells behave in vivo. Here, we have used two-photon Ca2+ imaging to monitor the activity of mossy cells in awake, behaving mice. We find that mossy cells are significantly more active than dentate granule cells in vivo, exhibit spatial tuning during head-fixed spatial navigation, and undergo robust remapping of their spatial representations in response to contextual manipulation. Our results provide the first characterization of mossy cells in the behaving animal and demonstrate their active participation in spatial coding and contextual representation.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

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Citations in the corpus

Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “Moreover, recent modelling found that deleting mossy cells in a computational model of the dentate gyrus increased pattern overlap because of the reduced disynaptic feedback inhibition (Chavlis et al., 2017; Danielson et al. 2017).”
Pattern separation in the hippocampus through the eyes of computational modeling (2017, methodology): “Chavlis et al. (2017) predicted that dendrites, along with a number of other mechanisms such as synaptic strengths, somatic dimensions, ionic conductances, and so forth. contribute to pattern separation by controlling sparsity in the GC population.”
An analysis of dentate gyrus function (an update) (2017, background): “It should also be noted that the mossy cells which form an intricate circuit with granule cells are generally more active than the granule cells in a variety of spatial situations [10,11].”