Candida albicans Biofilms and Human Disease
By C. Nobile, Alexander Johnson. Annual Review of Microbiology, 2015
1,001 citations recorded by the source corpus.
In humans, microbial cells (including bacteria, archaea, and fungi) greatly outnumber host cells. Candida albicans is the most prevalent fungal species of the human microbiota; this species asymptomatically colonizes many areas of the body, particularly the gastrointestinal and genitourinary tracts of healthy individuals. Alterations in host immunity, stress, resident microbiota, and other factors can lead to C. albicans overgrowth, causing a wide range of infections, from superficial mucosal to hematogenously disseminated candidiasis. To date, most studies of C. albicans have been carried out in suspension cultures; however, the medical impact of C. albicans (like that of many other microorganisms) depends on its ability to thrive as a biofilm, a closely packed community of cells. Biofilms are notorious for forming on implanted medical devices, including catheters, pacemakers, dentures, and prosthetic joints, which provide a surface and sanctuary for biofilm growth. C. albicans biofilms are intrinsically resistant to conventional antifungal therapeutics, the host immune system, and other environmental perturbations, making biofilm-based infections a significant clinical challenge. Here, we review our current knowledge of biofilms formed by C. albicans and closely related fungal species.
Subfields: Epidemiology, Infectious Diseases, Periodontics
View Paper: https://www.semanticscholar.org/paper/5e945268f6f8fd4d66044feb13a7f07654261596
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Epidemiology
In Infectious Diseases
In Periodontics
Citations in the corpus
- Candida albicans biofilms: development, regulation, and molecular mechanisms (2016, methodology): “albicans is a leading cause of hospital-acquired infections, it accounts for 15% of 89 all sepsis cases, and is the cause of 40% of bloodstream infections in clinical settings 90 [1].”
- Candida albicans—The Virulence Factors and Clinical Manifestations of Infection (2021, background): “albicans cells phagocytosed by host immune cells, direct damage of mucosal barriers, and spread from fungal biofilms [49,91].”