Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex

By Giorgio A. Ascoli, L. Alonso-Nanclares, S. Anderson, G. Barrionuevo, Ruth Benavides-Piccione, A. Burkhalter, György Buzsáki, B. Cauli, J. DeFelipe, A. Fairén and 29 more. Nature Reviews Neuroscience, 2008

1,516 citations recorded by the source corpus.

Neuroscience produces a vast amount of data from an enormous diversity of neurons. A neuronal classification system is essential to organize such data and the knowledge that is derived from them. Classification depends on the unequivocal identification of the features that distinguish one type of neuron from another. The problems inherent in this are particularly acute when studying cortical interneurons. To tackle this, we convened a representative group of researchers to agree on a set of terms to describe the anatomical, physiological and molecular features of GABAergic interneurons of the cerebral cortex. The resulting terminology might provide a stepping stone towards a future classification of these complex and heterogeneous cells. Consistent adoption will be important for the success of such an initiative, and we also encourage the active involvement of the broader scientific community in the dynamic evolution of this project.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/5e9183921fdc11da16aef47a2ea4ccc7483b8d6a

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Citations in the corpus

The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors (2010, methodology): “To parse out the 5-HT3AR population in this region in more detail, we an- alyzed their expression of a variety of neurochemical interneuron markers (Ascoli et al., 2008).”
Adult Mouse Cortical Cell Taxonomy by Single Cell Transcriptomics (2016, neutral): “…for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms based on quantitative features has been challenging, and our understanding of the extent of cell type diversity remains incomplete 4, 9, 10 .”
GABAA inhibition controls response gain in visual cortex (2011, background): “Information processing in sensory cortex relies on interactions between excitatory and inhibitory circuits, mediated by a diversity of GABAergic interneurons (Markram et al., 2004; Ascoli et al., 2008).”
Reconstruction and Simulation of Neocortical Microcircuitry. (2015, neutral): “…and Systems Lab, EPFL, 1015 Lausanne, Switzerland 17Imperial College London, London SW7 2AZ, UK 18Department of Neuroscience, Karolinska Institutet, Stockholm 17177, Sweden 19Co-first author 20Co-senior author *Correspondence: henry.markram@epfl.ch http://dx.doi.org/10.1016/j.cell.2015.09.029”
Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex (2010, neutral): “…of all neurons in the neocortex (Feldman and Peters, 1978; Kawaguchi and Kubota, 1997; Markram et al., 2004; Peters and Kara, 1985), where they display a remarkable diversity of subtypes as defined by morphological, molecular, and biophysical features (Ascoli et al., 2008; Burkhalter, 2008).”
Dense, Unspecific Connectivity of Neocortical Parvalbumin-Positive Interneurons: A Canonical Microcircuit for Inhibition? (2011, background): “Electrophysiologically, GFP-positive neurons were all fast-spiking cells, firing at frequencies 50 Hz (97 6 Hz, n 42) (Ascoli et al., 2008).”
Cellular Structure of the Human Cerebral Cortex (2009, background): “However, we still have no convention about how to name cortical neurons delineated in this manner (Ascoli et al., 2008).”
Interneuron dysfunction in psychiatric disorders (2012, background): “The various cortical interneuron subtypes have distinct or only partially overlapping morphological, electrophysiological and neurochemical characteristics, which makes their unequivocal identification a complex endeavou”